The publications from the Wyart lab are accessible on our website here: http://wyartlab.org/publications

Find out recent news on twitter: Claire's @ClaireWyart and the lab @wyartlab

Our lab combines genetics, biophysics, physiology & behavior to understand how sensory inputs are integrated in the spinal cord during development and active locomotion. The lab discovered that neurons contacting the cerebrospinal fluid (CSF) in the spinal cord are mechanoreceptors detecting curvature of the spinal cord and CSF flow, which modulate the activity of spinal neurons controlling locomotion and posture. We use the transparent zebrafish larva to implement optical methods for manipulating and monitoring neuronal activity in motion. Our work aims to unravel the mechanisms by which interoceptive sensory inputs are integrated throughout life to form the spinal cord, and insure homeostasis in the mature stages.

Three permanent researchers in the team:

Dr. Claire Wyart graduated from the Ecole Normale Supérieure Ulm in 2000. Under the supervision of Laurent Bourdieu and Didier Chatenay, she obtained her PhD in biophysics and neuroscience from the University of Strasbourg and moved to University of California in Berkeley for her postdoc. In the lab of Udi Isacoff, she developed optical techniques to control activity of neurons remotely in vivo (optogenetics). Dr. Wyart is EMBO Young investigator & EMBO full member, New York Stem Cell Foundation (NYSCF) Robertson Investigator, FENS-Kavli Network of Excellence (FKNE) Scholar and Board member. Commitment to science outreach and training in science: https://zenith-etn.com; https://en.adioscorona.org

Dr. Yasmine Cantaut-Belarif is a permanent researcher at CNRS since 2020. She did her PhD with Antoine Triller in the Ecole Normale Supérieure Ulm. During her postdoctorate fellowship in the Wyart's team between 2017 and 2020, she demonstrated the role of the Reissner fiber in the formation of the axis. Her research now tackles the molecular mechanisms by which the fiber can control the straightness of the body axis.

Prof. Hugues Pascal-Moussellard is a MD PhD and surgeon in charge of the orthopedic department of the Pitié-Salpêtrière hospital in Paris 13. He conducts with Laura Marie Hardy, Thomas Courtin and Prof. Alexis Brice a project aiming to decipher mutations associated with idiopathic scoliosis in humans.

Neuromodulation in the hindbrain and spinal cord

Arousal locomotion is strongly modulated by our inner physiological states. This spontaneous exploratory locomotion reflects the excitability of motor circuits in the spinal cord as well as descending commands from the brain, in particular from the hindbrain. The underlying mechanisms controlling the occurrence of spontaneous locomotion and its natural variability among animals and across physiological states within one animal are not well understood. On one end, we are interested in probing neuromodulatory pathways in the hindbrain and spinal cord for setting the frequency of occurrence of locomotion in the context of circadian rhythm, inflammation and feeding. On the other, we investigate how neuromodulation can influence morphogenesis.

Modulation of motor circuits via the cerebrospinal fluid

The classical view of spinal cord physiology relies on the fact that motor functions are carried by ventral spinal cord while dorsal spinal cord integrates sensory inputs from the periphery. Up to recently, there was no evidence that the vertebrate spinal cord hosts sensory cells conserved throughout vertebrates. Our team has shown evidence for a central sensory motor loop localized in the spinal cord and modulating circuits underlying locomotion and posture. We have evidence that the morphology and molecular markers of this central sensory system is conserved in the mammalian spinal cord. This axial sensory system modulates locomotion, posture and morphogenesis.

Sensory integration in the spinal cord throughout life

The contribution of mechanosensory feedback to active locomotion and the nature of underlying spinal circuits remain elusive. We investigate how mechanosensory feedback shapes active locomotion in the zebrafish larva. We find that mechanosensory feedback enhances the recruitment of motor pools during active locomotion. We show that inputs from glutamatergic mechanosensory neurons increase locomotor speed by prolonging fast swimming at the expense of slow swimming during stereotyped acoustic escape responses.

Moreover we have evidence that sensory integration is critical throughout life for growing and maintaining a straight body axis.

Altogether, our efforts reveal the basic principles and circuit diagram underlying the modulation of movement, posture and morphogenesis by adjusted mechanosensory feedback in the vertebrate spinal cord.

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  Yasmine Cantaut‑Belarif

  • Principal Investigator at CNRS

  Biography

  Yasmine Cantaut Belarif obtained her PhD from the Biological Department of the Ecole Normale Supérieure and University Pierre et Marie Curie (UPMC) in 2015 where she worked on interactions between immune cells and nervous system at the nanoscopic scale on proteins from inhibitory synapses in the dorsal spinal cord. After a postdoc in the lab in which she discovered that the Reissner fiber is critical for straightening the body axis, she obtained in 2020 a permanent researcher position in CNRS. In 2021, she successfully obtained the competitive French grant ANR JCJC to support the scientific autonomy of young researchers in France. Find more about Yasmine on Twitter here !

  Projects

  Yasmine studies the roles of scospondin and the Reissner fiber in axon pathfinding and the development of the spinal cord in zebrafish.

  Published

  • [2020] Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo
  • [2020] Origin and role of the cerebrospinal fluid bidirectional flow in the central canal
  • [2019] Central Sensory Neurons Detect and Combat Pathogens Invading the Cerebrospinal Fluid
  • [2018] The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis
  • [2018] Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
• 

  Clothilde Colart

  • Ph.D. student at Sorbonne Université (SU)

  Biography

  Clothilde did her first two years of bachelor at University of Lille with a major in Cell biology. After a gap year in Australia, she integrated the “Magistère Européen de Génétique” (University of Paris) for her last year of Bachelor, followed by her Master. There, she had the opportunity to do a 4-months internship in Porto (Portugal) in the team of Nuno dos Santos, where she learned techniques of molecular biology. Her long-term interest has always been the biology of Development, but she recently discovered with pleasure the world of Neurosciences. This year, she therefore followed the Pasteur’s course “Development & Plasticity of the Nervous System”. She’s happy to integrate the team for a 6-months internship, as part of her last year of Master, in order to study the molecular mechanisms underlying body axis straightening in the embryo.

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  Mahalakshmi Dhanasekar

  • Ph.D. student at Sorbonne Université (SU)
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  Zaineb El Bourakkadi

  • Engineer at ICM
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  Kevin Fidelin

  • Principal Investigator at ICM

  Biography

  Kevin received training in the Master of Genetics of University Paris Diderot. Kevin received his Ph.D. in Neuroscience in October 2016 from the University Pierre et Marie Curie in Paris.

  Projects

  Kevin now investigates the connectivity of glutamatergic touch-receptor neurons in the spinal cord, the Rohon-Beard neurons, in order to probe their role during swimming.Kevin investigates how peripheral and internal sensory feedback pathways control locomotion. He first established the connectivity of a conserved class of intraspinal sensory neurons, termed Cerebrospinal fluid-contacting neurons (CSF-cNs) in zebrafish and investigated the function of these inhibitory sensory neurons during locomotion using a combination of electrophysiology, optogenetics, and calcium imaging techniques.

  Published

  • [2021] Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed
  • [2019] Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities
  • [2017] Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion
  • [2016] Three-dimensional spatiotemporal focusing of holographic patterns,
  • [2016] Optimization of Botulinum toxin to probe the role of specific interneurons in innate locomotion
  • [2015] State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons
  • [2014] Inhibition and motor control in the developing zebrafish spinal cord
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  Faustine Ginoux

  • Engineer at ICM

  Biography

  Faustine is a software/research engineer who joined the lab in November 2020, after graduating from a master in Bioengineering specialized in Computational neurosciences (EPFL, Switzerland) as well as a second master in AI (KU Leuven, Belgium). Her interest is transdisciplinary and she wants to use computational methods to better understand the neuronal mechanisms underlying behavior. Faustine is currently analyzing the calcium activity of neurons in the hindbrain of larval zebrafish performing the optomotor response, and investigating directional neuronal communication with the aim of linking the neural activity to the locomotor behavior.

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  Joana Guedes

  • Principal Investigator at ICM

  Biography

  Joana received her PhD in Immunology in 2017 from Imperial College London, UK, studying the role of NKG2D in models of liver inflammation and tumorigenesis in the Lab of Dr Nadia Guerra. Passionate about collaboration, innovation and interdisciplinary in science, she then moved to working in research and project management in international universities and research funding agencies.

  Joana is now the project manager of the ZENITH European training programme (https://zenith-etn.com), an exciting interdisciplinary neuroscience-focused PhD network, that aims to train a new generation of neuroscientists in cutting-edge approaches that bridge biology, physics, mathematics and computer science to uncover the mysteries of brain formation and function.

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  Agnès Hocquemiller

  • Engineer at ICM

  Biography

  Agnès received a technician diploma in 2017. She entered EBI (Ecole de Biologie Industrielle), an engineering school based in Cergy, and graduated in 2021, with the specialization Research and Application. After an end-of study internship in developmental biology, working on C. elegans, she joined the lab in December 2021 as engineer. Her project consists in developing transgenic lines of zebrafish. Apart from biology, Agnès is passionate about music: choir, piano, flute, and loves playing rugby !

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  Xinyu Jia

  • Ph.D. student at Sorbonne Université (SU)

  Biography

  Xinyu Jia is a first year grad student who obtained a master in Optics as well as a master in Neuroscience in University of Edinburgh in Scotland. Xinyu was selected among >100 students for the ZENITH European training programme (https://zenith-etn.com).

  Projects

  Xinyu's PhD project focuses on investigating the function of descending command neurons to sustain distinct locomotor episodes using 3D optogenetics in vivo. She will be co-advised by Claire Wyart and Dimitri Tanese from the Emiliani lab in the vision institute.

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  Mathilde Lapoix

  • Ph.D. student at FIRE

  Biography

  After entering med school in Lyon in 2015, Mathilde joined the Ecole de l’Inserm Liliane Bettencourt in 2017 to follow a double joint path, in order to achieve an early formation to research along her medical studies. Her long-term interest on neural and muscular comprehension lead her to her first research internship in Lyon at Neuromyogene Institute on understanding the physiological and pathological regeneration of the muscle, and to her second internship in University of Ottawa, on the sensorimotor integration in the electric fish. Taking a gap year in her medical studies, she started a second year of master in Cellular and Integrated Neurosciences at Sorbonne University in September 2018. She joined Wyart’s team in October 2018 to work on circuits driving exploratory locomotion in Zebrafish.

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  Elias Lunsford

  • Postdoc at ICM

  Biography

  Trained in Ecology, Dr. Lunsford learned fish biomechanics and ethology.

  By pioneering a preparation to record the activity of lateral line in diverse species, Elias described the evolution of this sensory system in cave morphs of Astyanax and uncovered the hair cell transduction mechanism of fresh water fish.

  Elias is eager to learn molecular and optical techniques in zebrafish.

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  Giulia Messa

  • Postdoc at ICM

  Biography

  Giulia Messa is an expert of motor circuits in the brainstem ! she trained in the lab of Stella Koutsikou in the UK and joined the team to work with Yasmine Cantaut-Belarif on morphogenesis!

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  Olivier Mirat

  • Engineer at ICM

  Biography

  Olivier Mirat graduated from a computer science master program before joining the lab. He created the tracking software ZebraZoom1.0 and subsequent improvements. Now working as freelance, he often helps people in the lab.

  Projects

  Zebrafish larvae swim as discrete bouts lasting for a couple of hundreds of milliseconds every few seconds. Their movements are very fast. Olivier generated a tracking software combined with a brain machine interface to implement automated categorization of every swim bout. His algorithms have changed the way we process and analyse locomotion in our lab.

  Published

  • [2022] A lexical approach for identifying behavioural action sequences
  • [2021] Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed
  • [2013] ZebraZoom: an automated program for high-throughput behavioral analysis and categorization
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  Hugues Pascal Moussellard

  • Assistant Professor at UPMC

  Biography

  Hugues is M.D. Ph.D., professor at the university Pierre and Marie Curie Paris-6 and head of the orthopedics department of the Pitié-Salpêtrière hospital. He did his initial studies in Marseille and was trained by Catonnet in Martinique at the beginning of his career.

  Published

  • [2017] Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion
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  Feng Quan

  • Principal Investigator at ICM

  Biography

  Feng is an engineer who started a PhD in january 2017 in collaboration with the National Museum of Natural History with Prof. Hervé Tostivint.

  Projects

  Feng investigates the functional roles of proteins and peptides secreted in cerebrospinal fluid-contaction neurons(CSF-cNs) in zebrafish and in mammals.

  Published

  • [2021] Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed
  • [2019] Central Sensory Neurons Detect and Combat Pathogens Invading the Cerebrospinal Fluid
  • [2017] The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
  • [2015] Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons
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  Gautam Sridhar

  • Ph.D. student at ICM

  Biography

  Gautam Sridhar joined the Wyart Lab after finishing his MSc in Electrical Engineering at ETH Zurich. Gautam’s interests in machine learning translate to applying such methods to investigate the structure in the locomotion of larval zebrafish. As part of the ZENITH interdisciplinary training network, he will be supervised primarily by Dr. Claire Wyart in investigating the pattern of zebrafish locomotion in the presence of various stimuli and contexts. He will further work with Dr. Moritz Grosse-Wentrup at University of Vienna to investigate causal links between characteristic behaviour and neuronal activity.

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  Loeva Tocquer

  • Engineer at INSERM
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  Claire Wyart

  • Director of Research at INSERM
  • Team leader at ICM

  Biography

  Claire Wyart joined for her PhD the biophysics lab of Didier Chatenay in 2000 in the Institute of Physics in the University of Strasbourg. During her PhD, Claire developed novel methods for controlling the architecture of neuronal networks in vitro and demonstrated mechanisms underlying the emergence of spontaneous activity. After one year of teaching in Tibetan schools, she joined UC Berkeley for her postdoctoral fellowship in the labs of Prof. Noam Sobel and Ehud Isacoff between 2005 and 2010. There she developed optogenetic methods in vivo by taking advantage of the transparency of the zebrafish larva. In this small vertebrate model, Claire used optogenetics to study sensory-motor integration, analyzing the processing of visual, mechanosensory and chemosensory pathways modulating locomotion. Since 2011, her team has discovered a polymodal sensory system at the interface with the cerebrospinal fluid that detects spinal curvature as well as the chemical content of the fluid. Her team now investigates motor circuits in the brainstem that initiate and steer movement. Claire became an EMBO-Young Investigator (EMBO-YIP) and EMBO member in 2019. She received the Irene Joliot-Curie prize in 2013 & Richard Lounsbery prize between France and USA in 2022.

  The Wyart team received the support of the ATIP / Avenir from Inserm and CNRS with the Fondation Bettencourt-Schueller, a chair of excellence from the Ecole des Neurosciences de Paris (ENP) and the emergence programme of the City of Paris. Subsequently, her team received support from the European Research Council (ERC) Starting Grant in 2012 and Consolidator Grant in 2020, the Human Frontier Science Program (HFSP) research grant in 2013 and 2017, and a National Institute of Health (NIH) research grant from 2014 and 2018. She became an EMBO-Young Investigator (EMBO-YIP) in 2016, an EMBO member in 2019. She received the New York Stem Cell Foundation (NYSCF) Robertson Innovation in Neuroscience award in 2016. She received the award from the Foundation for Scientific Education and Research (FSER) in 2017 and the Richard Lounsbery prize between France and USA in 2022.

  Projects

  Claire is interested by deciphering thel neuronal circuits that integrate information from the brain, from the periphery and from internal cues in order to modulate locomotion and posture as a function of our inner physiological states. Her strategy is to take advantage of the transparency of zebrafish larva to develop methods for monitoring and manipulating neuronal activity during behavior. The lab now combines functional studies with molecular profiling to identify cell identity underlying functional diversity of neurons in sensory-motor integration. A major emphasis of the lab focuses on the investigation of GABAergic sensory neurons interfacing the cerebrospinal circuits with motor circuits in the vertebrate spinal cord. Another focus of the lab lies in understanding the functional connectivity between neurons across the hindbrain and spinal cord using functional population calcium imaging. The third interest of the lab lies in the role of mechanosensory feedback from the periphery in shaping the dynamics of active locomotion. Our main collaborators include Mario Chavez in ICM, Filippo Del Bene in Curie Institute, Herve Tostivint in the Museum National d’HistoireNaturelle (MNHN).

  In the pipeline

  • Title of chapter under review
  • Title of submitted article

  Published

  • [2022] Lateral line integrates mechanical and chemical cues to control exploration
  • [2022] A lexical approach for identifying behavioural action sequences
  • [2021] Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed
  • [2020] Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo
  • [2020] Origin and role of the cerebrospinal fluid bidirectional flow in the central canal
  • [2019] Building behaviors, one layer at a time
  • [2019] Simultaneous fluorescence imaging of tilted focal planes at two depths in thick neural tissue: Implementation with remote focus in a widefield electrophysiological microscope
  • [2019] Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities
  • [2019] Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons
  • [2019] Motor control systems of the spinal cord and hindbrain. Curr Opin Physiol (COP)
  • [2019] Glia: A Gate Controlling Animal Behavior?
  • [2019] Central Sensory Neurons Detect and Combat Pathogens Invading the Cerebrospinal Fluid
  • [2018] Taking a big step towards understanding locomotion
  • [2018] The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis
  • [2018] Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
  • [2018] Active mechanosensory feedback during locomotion in the zebrafish spinal cord
  • [2018] Investigation of hindbrain activity during active locomotion reveals inhibitory neurons involved in sensorimotor processing
  • [2017] Locomotion: Control from the Periphery?
  • [2017] The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
  • [2017] Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion
  • [2017] Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae
  • [2017] Light on a sensory interface linking the cerebrospinal fluid to motor circuits in vertebrates
  • [2017] Quick Guide: Cerebrospinal fluid-contacting neurons
  • [2017] Tracking microscopy enables whole-brain imaging in freely moving zebrafish
  • [2016] Sensory circuits in motion
  • [2016] A brain conditioned for social defeat
  • [2016] CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
  • [2016] Remote z-scanning with an acroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy
  • [2016] Three-dimensional spatiotemporal focusing of holographic patterns,
  • [2016] Optimization of Botulinum toxin to probe the role of specific interneurons in innate locomotion
  • [2016] Locomotion: Electrical Coupling of Motor and Premotor Neurons
  • [2016] Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion
  • [2015] Optogenetic neuromodulation: new tools for monitoring and breaking neural circuits
  • [2015] Sensorimotor Integration in the Spinal Cord, from Behaviors to Circuits: New Tools to Close the Loop? New Techniques in Systems Neuroscience
  • [2015] Fast Calcium Imaging with Optical Sectioning via HiLo Microscopy
  • [2015] Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons
  • [2015] Neuronal Wiring: Linking Dendrite Placement to Synapse Formation
  • [2015] Hierarchy of neural organization in the embryonic spinal cord: Granger-Causality graph analysis of in vivo calcium imaging data
  • [2015] Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3
  • [2015] State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons
  • [2014] Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates
  • [2014] Endothelial cilia mediate low flow sensing during zebrafish vascular development
  • [2014] Inhibition and motor control in the developing zebrafish spinal cord
  • [2013] ZebraZoom: an automated program for high-throughput behavioral analysis and categorization
  • [2013] Optogenetics in a transparent animal: circuit function in the larval zebrafish
  • [2013] Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway
  • [2012] Emergence of patterned activity in the developing zebrafish spinal cord
  • [2012] Optogenetics: a new enlightenment age for zebrafish neurobiology
  • [2011] Let there be light: zebrafish neurobiology and the optogenetic revolution
  • [2010] Filtering of visual information in the tectum by an identified neural circuit
  • [2010] A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
  • [2009] Optogenetic dissection of a behavioural module in the vertebrate spinal cord
  • [2008] Colloid-guided assembly of oriented 3D neuronal networks
  • [2007] Smelling a single component of male sweat alters levels of cortisol in women
  • [2007] Remote control of neuronal activity with a light-gated glutamate receptor
  • [2006] Ultrafast random-access scanning in two-photon microscopy using acousto-optic deflectors
  • [2005] Dynamics of excitatory synaptic components in sustained firing at low rates
  • [2005] A new technique to control the architecture of neuronal networks in vitro
  • [2002] Constrained synaptic connectivity in functional mammalian neuronal networks grown on patterned surfaces
  • [1999] Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer’s disease

In the pipeline

• John Doe, Claire Wyart, Wyart, C, Wyart C. Title of chapter under review under revision.
• John Doe, Claire Wyart, Wyart, C, Wyart C, Bohm U. Title of submitted article. Non existing Review;42(1):23–42. submitted.

Latest Publications

• Desban, L, Roussel, J, Michalski, N, Wyart, C#. Lateral line integrates mechanical and chemical cues to control exploration. bioRxiv. 2022 Aug 30.
  • DOI:10.1101/2022.08.31.505989
• Reddy G#, Desban L, Tanaka H, Roussel J, Mirat O, Wyart C#. A lexical approach for identifying behavioural action sequences. PLoS Comput Biol. 2022 Jan 9;18(1):e1009672.
  • DOI:10.1371/journal.pcbi.1009672
  • Download PDF
• Ming-Yue Wu, Martin Carbo-Tano, Olivier Mirat, Francois-Xavier Lejeune, Julian Roussel, Feng B Quan, Kevin Fidelin, Claire Wyart. Spinal sensory neurons project onto the hindbrain to stabilize posture and enhance locomotor speed. Curr Biol. 2021 Aug 8;31(15):3315-3329.e5.
  • DOI:10.1016/j.cub.2021.05.042
• Orts-Del’Immagine, A, Cantaut-Belarif, Y,*, Thouvenin, O, Roussel, J, Baskaran, A, Langui, D, Koeth, F, Bivas, P, Lejeune, FX, Bardet, PL, Wyart C#. Sensory neurons contacting the cerebrospinal fluid require the Reissner fiber to detect spinal curvature in vivo. Current Biology. 2020. in press..
  • Download PDF
• Thouvenin, O, Keiser, L, Cantaut-Belarif, Y, Carbo-Tano, M, Verweij, F, Jurisch-Yaksi, N, Bardet, PL, Van Niel, G, Gallaire, F, Wyart C #. Origin and role of the cerebrospinal fluid bidirectional flow in the central canal. eLife. 2020 Jan 8;pii:e47699.
  • DOI:10.7554/elife.47699
  • Download PDF
• Wyart C, Thirumalai V. Building behaviors, one layer at a time. eLife. 2019;8:e46375.
  • DOI:10.7554/elife.46375
  • Download PDF
• Lagarde B, Russell N, Esposito E, Desban L, Wyart C, Ogden D. Simultaneous fluorescence imaging of tilted focal planes at two depths in thick neural tissue: Implementation with remote focus in a widefield electrophysiological microscope. biorxiv. 2019.
  • DOI:10.1101/839050
  • Download PDF
• Bercier V, Hubbard JM, Fidelin K, Duroure K, Auer TO, Revenu C, Wyart C#, Del Bene F#. Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Mol Neurodegener. 2019 Jul 9;14(1):1–22.
  • DOI:10.1186/s13024-019-0327-3
  • Download PDF
• Desban, L, Prendergast, A, Roussel, J, Rosello, M, Geny, D, Wyart C#, Bardet, PL. Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology. 2019;17(4):e3000235.
  • DOI:10.1371/journal.pbio.3000235
  • Download PDF
• Miles G, Wyart C. Motor control systems of the spinal cord and hindbrain. Curr Opin Physiol (COP). 2019.
  • DOI:10.1016/j.cophys.2019.04.003
  • Download PDF
• Wyart C, Prendergast A. Glia: A Gate Controlling Animal Behavior?. Current Biology. 2019;29:R847-R850.
  • DOI:10.1016/j.cub.2019.07.058
  • Download PDF
• Prendergast, AE, Jim, KK, Marnas, H, Desban, L, Quan, F, Djenoune, L, Roussel, J, Cantaut-Belarif, Y, Sahu, S, Bardet, PL, van de Beek, D, Vandenbroucke-Grauls, C#, Wyart, C#. Central Sensory Neurons Detect and Combat Pathogens Invading the Cerebrospinal Fluid. 2019. CELL-D-19-01614.

See all publications